Meta-Analysis: Smoking May Play “Causative Role” In Psychotic Illness

Medscape (7/24, Melville) reported that a new meta-analysis published in The Lancet Psychiatry suggests that “smoking itself may play a causative role in the development of psychotic illness.” The analysis, which “included 61 studies with data through 2014 involving 14,555 tobacco smokers and 273,162 nonsmokers,” including international populations, found that “57% of people with a first episode of schizophrenia were already smokers, for an overall odds ratio of 3.22 (95% confidence interval [CI], 1.63 – 6.33), with some evidence of publication bias.” In addition, “daily smokers were still approximately twice as likely to develop new psychotic disorders as nonsmokers (relative risk, 2.18; 95% CI, 1.23 – 3.85)” and developed such disorders about one year earlier than nonsmokers.

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