MedPage Today (10/19, George) reports the narcolepsy medications “modafinil (Provigil) and armodafinil (Nuvigil) were both associated with major congenital malformations,” investigators concluded in “a post-marketing report.” That report revealed that “of 102 prospective live births in the U.S. Provigil/Nuvigil Pregnancy Registry, 13% had major congenital malformations, considerably above the prevalence of about 3% in the general population.” The findings were published online in a research letter in JAMA Internal Medicine.
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