Medscape (6/9, Yasgur, Subscription Publication) reported, “Patients with ‘treatment-resistant depression’ may be taking other medications with side effects that interfere with antidepressant efficacy,” researchers concluded after having “studied over 800 patients who were taking antidepressants for major depressive disorder.” The study revealed that “close to two thirds were taking at least one nonpsychiatric medication with potential depressive symptom side effects (PDSS) more than 30% were taking two or more such medications, and 20% at least three such medications.”
In fact, such “medications, which included antihypertensive medications and corticosteroids, among others, were associated with higher odds of moderate-to-severe depressive symptoms, compared with medications without PDSS.” The findings were published online May 24 in the Journal of Clinical Psychiatry.
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