MedPage Today (7/1, DePeau-Wilson ) reports, “Multiple first-line antidepressant medications were broadly linked with weight gain, although bupropion (Wellbutrin) had the least amount of weight change, according to observational data.” In a two-year study, “the estimated weight gain was lower for bupropion compared with sertraline (Zoloft) – the most commonly prescribed antidepressant in the analysis – at 6 months (difference -0.80 kg, 95% CI -1.26 to -0.42 kg), according to” researchers. Additionally, six-month weight gain was higher for “escitalopram (Lexapro): difference 0.41 kg (95% CI 0.31-0.52 kg); paroxetine (Brisdelle): difference 0.37 kg (95% CI 0.20-0.54 kg); duloxetine (Cymbalta): difference 0.34 kg (95% CI 0.22-0.44 kg); venlafaxine (Effexor): difference 0.17 kg (95% CI 0.03-0.31 kg);” and “citalopram (Celexa): difference 0.12 kg (95% CI 0.02-0.23 kg)” than bupropion. These results were published in Annals of Internal Medicine.
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