Psychiatric News (2/28) reported a study suggests that “patients with dementia taking some antidepressants,particularly selective serotonin reuptake inhibitors (SSRIs), experienced faster cognitive decline compared with those not taking these medications.” According to the study, “adults taking antidepressants experienced faster cognitive decline during follow-up compared with non-use (an additional 0.3-point loss on the MMSE per year). Among adults who had severe dementia at baseline, those taking antidepressants experience an additional 1.5-point loss on the MMSE per year.” In particular, “three SSRIs on the list – escitalopram, sertraline, and citalopram – were associated with greater cognitive decline compared with non-use. Compared with sertraline, escitalopram presented with faster cognitive decline, while citalopram was linked to a slower cognitive decline.” The study was published in BMC Medicine.
Related Links:
— “SSRIs Associated With Faster Cognitive Decline in Patients With Dementia,” Psychiatric News, February 28, 2025