Adverse events reported in placebo arms of COVID-19 vaccine trials disproportionately high, systematic review suggests

MedPage Today (1/18, Walker) reports, “While more adverse events (AEs) were reported among those who received the COVID-19 vaccine during clinical trials versus placebo, the number of AEs reported in the placebo group was disproportionately high, a systematic review and meta-analysis found.” According to the review, “about a third of placebo recipients reported at least one systemic AE following both doses,” and these “so-called ‘nocebo responses’ in the active arms likely accounted for 76% of the reported systemic AEs after the first vaccine dose and 52% of AEs after the second vaccine dose.” The findings were published in JAMA Network Open.

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