MedPage Today (12/22, Robertson) reports a study found that “use of benzodiazepines during pregnancy, particularly in the second trimester, was linked to some adverse pregnancy outcomes.” Researchers observed that “among 454,477 pregnancies, benzodiazepine use was associated with increased risk of abortion (spontaneous and elective abortion), with an absolute risk of 0.83 events per 100 pregnancies among benzodiazepine users compared with 0.52 events per 100 in nonusers (relative risk [RR] 1.58).” Furthermore, they noted that “after accounting for competing risks, benzodiazepine use was also linked to increased risk of preterm birth (RR 1.20) and small for gestational age (RR 1.06), compared to nonuse, and effects were more pronounced with exposure during the second trimester.” The study was published in JAMA Internal Medicine.
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