Older patients prescribed atypical antipsychotic for hospitalization-related delirium often stayed on past recommended duration

According to MedPage Today (2/17), “Older patients prescribed an atypical antipsychotic for hospitalization-related delirium more often stayed on it past the recommended duration than if prescribed a typical antipsychotic, researchers reported.” They found that “among nearly 6,000 patients 65 and older without prior psychiatric disorders, 13.5% were newly prescribed haloperidol and 86.5% initiated an atypical antipsychotic to treat delirium around an infection-related hospitalization.” The findings were published in JAMA Network Open.

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Cognitive function improves after cochlear implantation for older adults with severe hearing loss

MedPage Today (2/16, George) reports, “Cognitive functioning improved 12 months after cochlear implantation for older adults with severe hearing loss and poor cognition, datafrom a single-center study showed.” Among the “21 cochlear implant candidates whose preoperative scores indicated mild cognitive impairment, overall cognitive scores improved 12 months after cochlear implant activation from a median percentile of 5 to 12…reported” researchers in JAMA Otolaryngology-Head & Neck Surgery. The article adds, “Speech recognition in noise improved, which was tied to a rise in cognitive abilities.”

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Guideline On Use Of Opioids To Manage Chronic Pain Recommends Buprenorphine For Patients Requiring Long-Term Opioid Therapy

Psychiatric News (2/16) reports, “In their most recent guideline on the use of opioids to manage chronic pain, the U.S. departments of Veterans Affairs (VA) and Defense (DoD) recommend against using full agonist opioids…for patients who require daily pain management.” Instead, “the guideline, which was approved in May 2022, recommends using buprenorphine for patients who require long-term opioid therapy.” A reportpublished online Feb. 14 in the Annals of Internal Medicine summarized that guideline.

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— “VA, DoD Recommend Buprenorphine Over Full Agonist Opioids for Chronic Pain, Psychiatric News, February 16, 2023

Among ED Patients With COVID-19, Those With Both Psychiatric, Substance Use Disorders May Have Greater Odds Of Hospitalization Compared With Those With One Or Neither Type Of Disorder, Researchers Say

Healio (2/16, VanDewater) reports, “Among patients with COVID-19 who visited” emergency departments (EDs), “those with both psychiatric and substance use disorders had greater odds of hospitalization compared with those with one or neither type of disorder,” researchers concluded in a study that “analyzed discharge data for adults with COVID-19 at 873 hospitals with EDs and inpatient facilities in 48 states from April 2020 to August 2021,” then “also assessed incidence of substance use and psychiatric disorders using records from previous hospital visits or the first visit for COVID-19.” The findings were published online Feb. 15 in JAMA Psychiatry.

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— “Comorbid psychiatric, substance use disorders increase odds of COVID-19 hospitalization “Kalie VanDewater, Healio, February 16, 2023

Multiple demand network operates similarly in brains of children and adults

HealthDay (2/15, Murez) reports that for a study published in The Journal of Neuroscience, researchers “used brain scans and challenging work to assess how kids and adults might work through…tough problems and whether or not their problem-solving processes were the same.” The team “found that while the multiple demand network is not fully developed in kids, it operates similarly to the way it does in adults, said” the senior study author who explained, “We found that the multiple demand network was a distinct network even in young children, and was separate from the language network, just as it is in adults.”

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— “Young Kids, Adults Use Same Brain Areas to Solve Tough Problems “Cara Murez, HealthDay, February 15, 2023

FDA Panel Recommends Making Naloxone Available Over The Counter

The New York Times (2/15, Hoffman) reports two FDA “panels of addiction experts on Wednesday unanimously recommended that” naloxone (Narcan), “the overdose-reversing nasal spray, be made widely available without a prescription, a significant step in the effort to stem skyrocketing drug fatalities.”

The AP (2/15, Perrone) reports the “experts voted unanimously in favor of the switch after a full day of presentations and discussions centered on whether untrained users would be able to safely and effectively use the nasal spray in emergency situations.” The agency “will make a final decision on the drug in coming weeks.”

CNN (2/15, Christensen) reports the agency “has advised the industry to change the label to add simple directions for use and possibly instructions to call 911 after administering the drug.”

Bloomberg Law (2/15, Meghjani, Baumann, Subscription Publication) and NBC News (2/15, Lovelace) also report.

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— “Panel backs moving opioid antidote Narcan over the counter “Matthew Perrone, AP, February 15, 2023

Compared With Pre-Pandemic Years, Substance Use Appears To Have Decreased Among Adolescents, Young Adults In 2020, Research Suggests

Healio (2/15, Rhoades) reports, “Despite ‘significant stressors’ that emerged from the COVID-19 pandemic, substance use decreased among adolescents and young adults in 2020 compared with pre-pandemic years,” investigators concluded. In fact, “results from the NIDA-supported Monitoring the Future” survey revealed that “the percentage of 8th-, 10th- and 12th-graders reporting drug use decreased significantly as the pandemic endured, consistent with…findings” that show “marked reduction in substance use among youth aged 13 to 20 years in 2020.” The study authors concluded that “the ‘massive shifts to social functioning’ early in the pandemic led to abrupt discontinuations of data collection on national substance use,” according to the findings published online Jan. 31 in JAMA Network Open.

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— “Substance use decreased among youth, young adults during COVID-19 pandemic “Andrew Rhoades, Healio, February 15, 2023

As Many As 7% Of US Veterans May Have Positive Screen For Prolonged Grief Disorder, Study Indicates

Psychiatric News (2/15) reports, “As many as 7% of U.S. veterans were found to have a positive screen for prolonged grief disorder,” investigators concluded in a study that “analyzed data from the National Health and Resilience in Veterans Study, which surveyed a nationally representative sample of 2,441 U.S. veterans.” After adjusting for confounding factors, the study team found that “veterans with prolonged grief disorder were five to nine times more likely to screen positive for PTSD, major depressive disorder, and generalized anxiety disorder,” and “after additional adjustment for current psychiatric and substance use disorders, veterans were two to three times more likely to endorse suicidal thoughts and behaviors.” The findings were published online Feb. 13 ahead of print in the American Journal Of Geriatric Psychiatry.

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— “Prolonged Grief Disorder Among Veterans Linked to Risk of Other Psychiatric Disorders, Suicide, Psychiatric News, February 15, 2023

Lower state-level educational quality may be tied to higher dementia risk

According to HealthDay (2/14, Mozes), after spending “decades tracking the onset of dementia among nearly 21,000 U.S. seniors,” investigators found that “seniors who, as kids, were educated in states that generally had shorter school years, larger classes, and lower attendance rates had a higher risk for dementia after age 65, compared with seniors raised in states offering a ‘high quality’ education, meaning more school days, smaller classes and better attendance.” The findings were published online in JAMA Neurology.

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— “Poorer Schools Could Bring Higher Dementia Rates Many Decades Later “Alan Mozes, HealthDay, February 14, 2023

People Who Binge-Drink May Benefit From Taking Dose Of Naltrexone Before Consuming Alcohol, Small Study Indicates

According to the New York Times (2/14, Alcorn), new research “adds to the evidence that people who binge-drink may benefit from taking a dose of the medication naltrexone before consuming alcohol.” In the “randomized,” double-blinded study, the findings of which were “published in December in the American Journal of Psychiatry,” a publication of the American Psychiatric Association, “120 men who wanted to reduce bingeing but were not severely dependent on alcohol were given naltrexone to take whenever they felt a craving for alcohol or anticipated a period of heavy drinking.” At “the end of the 12-week study, those given naltrexone reported bingeing less frequently and consuming less alcohol than those who had been given a placebo, a change that lasted for up to six months.”

Related Links:

— “Binge Drinking May Be Curbed With a Pill “Ted Alcorn, The New York Times, February 14, 2023