The New York Times (9/12, Caron ) reports a new study published Thursday in The American Journal of Psychiatry “found that among people who took high doses of prescription amphetamines such as Vyvanse and Adderall, there was a fivefold increased risk of developing psychosis or mania for the first time compared with those who weren’t taking stimulants.” Investigators also found that a medium dosage “was associated with a 3.5 times higher risk of psychosis or mania.” Meanwhile, investigators identified “no increased risk of psychosis or mania among those who used methylphenidate drugs, like Concerta or Ritalin, regardless of the dose.”
Healio (9/12, Viguers) reports the case-control study “included 1,374 case patients with new-onset psychosis or mania and 2,748 matched controls, all of whom were hospitalized between 2005 and 2019.”
HCPlive (9/12, Derman) says that while “this study does not prove causality, investigators observed a plausible biological mechanism in neurobiological changes: a release of greater levels of dopamine from amphetamines. The dopaminergic changes mimic changes observed in patients with psychosis.”
According to Psychiatric News (9/12), researchers also “found that patients with any past-month prescription amphetamine use were 2.7 times more likely to develop psychosis or mania than those with no use.”
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