Medwire News (4/22, McDermid) reports, “A Mendelian randomization analysis supports a direct effect of major depressive disorder (MDD) on type 2 diabetes [T2D] risk, but produces no evidence for the reverse scenario,” researchers concluded after considering “89 single nucleotide polymorphisms (SNPs) with an established association with the risk for MDD.” The study team learned that “as people’s chances of developing MDD increased, based on their genetic liability, so too did their chances of having” T2D. After examining “the reverse situation, using 184 SNPs with a role in the risk for” T2D, investigators “found no association with the likelihood of developing MDD.” The findings were published online April 8 in the journal Diabetologia.
Related Links:
— “Genetics casts doubt on bidirectional depression, diabetes association, “Eleanor McDermid, Medwire News, April 22, 2020