Parkinson’s News Today (2/22, Maia) reports, “Among several atypical antipsychotics, Nuplazid (pimavanserin) seems to be the most effective at easing Parkinson’s disease psychosis…while sparing motor function,” researchers concluded in the findings of a 19-study systematic review and network meta-analysis that “evaluated outcomes with Nuplazid and other atypical antipsychotics such as clozapine, quetiapine, olanzapine, ziprasidone, and risperidone.” The findings were published online in the Journal of Geriatric Psychiatry & Neurology.

Related Links:

— “Nuplazid, clozapine treat Parkinson’s psychosis without motor decline “Margarida Maia, Parkinson’s News Today, February 22, 2023

MedPage Today (2/21, George) reports, “Being and remaining physically active throughout adulthood was linked with higher cognition at age 69,” researchers concluded in a study that “followed 1,417 participants in the 1946 British Birth Cohort, a long-running U.K. study of people born the same week in 1946.” The study revealed that “effect sizes were similar across all adult ages, suggesting that being physically active at any time in adulthood – even as little as once a month – was tied to higher cognition.” The findings were published online in the Journal of Neurology, Neurosurgery, and Psychiatry.

Related Links:

— MedPage Today (requires login and subscription)

Psychiatric News (2/21) reports that last week, the FDA ‘s “Nonprescription Drugs Advisory Committee and the Anesthetic and Analgesic Drug Products Advisory Committee voted unanimously, 19-0, to recommend that Narcan (naloxone HCl) 4 mg nasal spray be made available without a prescription, Emergent BioSolutions announced” in a Feb. 15 press release. Naloxone “reverses an opioid overdose by blocking the effects of opioids.” While the agency “is not bound by the committees’ guidance,” it “will take their advice into consideration when it makes its decision on whether to make the drug available over the counter (OTC).” The approval decision is “expected by March 29.”

Related Links:

— “FDA Advisory Panel Recommends Approval for Over-the-Counter Narcan, Psychiatric News, February 21, 2023

MedPage Today (2/20, George) reports, “Neurodegenerative pathologies have shown few differences over time despite falling dementia incidence rates,” investigators concluded after examining “brain autopsy data” from “over 1,500 deceased people from birth epochs spanning 25 years (1905-1930).” The study also revealed, however, that “brain atherosclerosis and arteriosclerosis were dramatically lower over the years.” The findingswere published online in JAMA Neurology.

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— MedPage Today (requires login and subscription)

According to Healio (2/20, Weldon), the findings of a 32-study “systematic review and meta-analysis” published online Feb. 20 in JAMA Pediatrics revealed that “22% of children and adolescents exhibit disordered eating.” The 32 studies encompassed “63,181 participants from 16 countries.”

Related Links:

— “‘Incredibly high’ proportion of children exhibit disordered eating behaviors “Rose Weldon, Healio , February 20, 2023