Psychiatric News (9/6) reported, “Along with aripiprazole and risperidone, olanzapine and perphenazine should be considered first-line antipsychotics for patients with schizophrenia, according to a clinical perspective.” According to Psychiatric News, “given its demonstrated effects on hostility, the researchers believe olanzapine is a preferred first-line choice for patients for whom aggression may be a concern, with clozapine as a second-line medication.” The perspective was published in Schizophrenia.

Related Links:

— “Researchers Propose Olanzapine and Perphenazine as First-Line Schizophrenia Treatments, Psychiatric News, September 6, 2024

HealthDay (9/5, Thompson ) reports “ketamine is becoming a popular depression drug, but” physicians are not “keeping in mind the danger it can pose to a pregnancy, a new study warns.” Ketamine may “be very harmful to a developing fetus and should not be used during pregnancy, researchers said.” However, “only 20% of ketamine clinics require a pregnancy test at least once prior to or during treatment, according to” study results. Additionally, “only 26% of clinics discuss the potential need for contraception with” patients using ketamine, “and fewer than 15% specifically recommend or require contraception use during ketamine treatment, researchers found.” The findings were published in the Journal of Clinical Psychiatry.

Related Links:

— “Ketamine Can Fight Depression, But Pregnant Women Face Risks,”
Dennis Thompson, HealthDay, September 5, 2024

Psychiatric News (9/5) reports, “About 4% of individuals with a neuropsychiatric disorder had a serious adverse event – including worsening depression, suicidal behavior, psychosis, or convulsions – after being given a ‘classic’ psychedelic as part of a research study, according to a meta-analysis that spanned some 75 years.” The research “identified no such adverse events among healthy participants; at the same time, tracking of such events should be improved, the study researchers wrote.” The findings were published in JAMA Psychiatry.

Related Links:

— “Study Finds Roughly 4% Of Individuals With Neuropsychiatric Disorder Have Serious Adverse Event After Being Given Psychedelic As Part Of Research, Psychiatric News , September 5, 2024

Healio (9/5, Mahoney) reports, “High-dose psilocybin showed the potential to treat depressive symptoms, although the effect size appeared small and comparable to that of escitalopram, according to results of a network meta-analysis.” The researchers “performed a sensitivity analysis that included only patients with major depressive disorder and found that the relative effects of escitalopram, ayahuasca and high-dose psilocybin had better responses than placebo in antidepressant trials.” The findings were published in The BMJ.

Related Links:

— “High-dose psilocybin may help treat depressive symptoms, with small effect size,”Moira Mahoney, Healio, September 5, 2024

MedPage Today (9/4, DePeau-Wilson ) reports, “Having a medical condition was associated with an increased risk of suicide in a dose-response-like manner, such that the higher the burden of disability, the higher the risk of suicide, according to an observational study in Denmark.” An analysis of over “6.6 million people found that nine medical condition categories including 31 specific conditions were associated with a statistically significant increased risk of suicide, with the exception of endocrine disorders.” Researchers found “the associations were most pronounced for gastrointestinal conditions… cancers…and hematological conditions.” The findings were published in JAMA Psychiatry. “ Individuals with mental disorder requiring psychiatric hospital treatment appear to be at such elevated risk of suicide that additional disability associated with medical conditions has little impact in this regard.”

Related Links:

— MedPage Today (requires login and subscription)