HealthDay (10/22, Gordon) reports, “The commonly used antidepressant Prozac [fluoxetine] doesn’t appear to help reduce obsessive-compulsive behavior in children and teens with autism,” researchers concluded in a study that “recruited nearly 150 children and teens with autism,” only 109 of which “completed the study.” The findings were published online Oct. 22 in JAMA.

Medscape (10/22, Anderson, Subscription Publication) reports that all “study participants had ‘significant problems’ with obsessive-compulsive behaviors, with a total score of six or more on the Children’s Yale-Brown Obsessive Compulsive Scale–Modified for pervasive developmental disorders (CYBOCS-PDD).” But, “commenting for Medscape Medical News, Gabrielle L. Shapiro, MD, clinical professor of psychiatry at the Icahn School of Medicine at Mount Sinai in New York City, and chair of the American Psychiatric Association…council on children, adolescents and families, described the study as ‘somewhat flawed.’” Besides “the CYBOCS, the inclusion of other outcome scales ‘more specific’ to” children with autism “in the primary analysis may have produced different results, said Shapiro, who was not involved with the current study.”

Healio (10/22, Gramigna) reports that the author of an accompanying editorial “emphasized the nullification of the overall findings by the prespecified analyses.” He wrote, “Despite the limitations, the outcome…is consistent with similar trials and contributes new evidence that SSRIs do not add any value over placebo for repetitive behaviors in children and adolescents with ASD as captured in the CYBOCS-PDD.” The editorialist called for “additional rigorous studies…both to identify other potential treatments for core symptoms and, for SSRIs, to determine whether clinical indications other than repetitive behaviors might account for their persistent widespread use in ASD.”

Related Links:

— “Antidepressant Doesn’t Ease Obsessive Behaviors of Autism, “Serena Gordon, HealthDay, October 22, 2019

The Washington Post (10/21, Wan) reports, “In the face of rising rates of depression, anxiety and suicide among young people, some states and school systems have” now begun “allowing students to take mental sick days off from school.” For example, in 2018 “Utah changed its definition of valid excuses for absences to include mental health issues,” and this past summer, “Oregon enacted a law – driven by a group of high school student activists – that allows students to take days off for mental health.” Meanwhile, “students in other states, including Colorado, Florida and Washington, are attempting to get similar laws passed.”

Related Links:

— “Schools now letting students stay home sick for mental-health days, “William Wan, The Washington Post, October 21, 2019

The NPR (10/21, Hamilton) “Shots” blog reports neuroscientists “are offering a new reason to control blood sugar levels: It might help lower your risk of developing Alzheimer’s disease.” This past Sunday, at the Society for Neuroscience meeting in Chicago, investigators presented “new research exploring the links between Alzheimer’s and diabetes.”

Related Links:

— “Keeping Your Blood Sugar In Check Could Lower Your Alzheimer’s Risk, “Jon Hamilton, NPR, October 21, 2019

Patients taking high doses of loperamide in an attempt to self-manage opioid withdrawal or to achieve a euphoric high may be at risk of severe cardiac events. If you suspect that a patient is misusing loperamide, ask your patient: Have you been taking loperamide? How much loperamide do you take and how often? Are you aware of the severe heart risks associated with loperamide misuse? Learn more about loperamide misuse, including the right questions to ask your patients, at LoperamideSafety.org.

Related Links:

— “Understanding Loperamide Abuse

Healio (10/21, Gramigna) reports, “Children whose fathers have poor mental health are more than twice as likely also to have poor mental health,” researchers concluded after using “data for 75,879 children from the 2011 to 2012 National Survey of Children’s Health” to estimate “prevalence and odds of poor mental and physical health among children based on the overall and mental health status of fathers, as well as pertinent sociodemographic covariates.” The findings were published online Oct. 9 in the journal Health Equity.

Related Links:

— “Child mental health status may be closely linked to father’s, “Joe Gramigna, Healio, October 21, 2019