The New York Times (5/6, Belluck ) reports, “Scientists are proposing a new way of understanding the genetics of Alzheimer’s that would mean that up to a fifth of patients would be considered to have a genetically caused form of the disease.” The concept “involves a gene variant called APOE4. Scientists have long known that inheriting one copy of the variant increases the risk of developing Alzheimer’s, and that people with two copies, inherited from each parent, have vastly increased risk.”

The AP (5/6, Neergaard ) reports that now, “research published Monday suggests that for people who carry not one but two copies of the gene, it’s more than a risk factor, it’s an underlying cause of the mind-robbing disease.” Additionally, for these patients, “symptoms can begin seven to 10 years sooner than in other older adults who develop Alzheimer’s.” Around “15% of Alzheimer’s patients carry two copies of APOE4.”

Reuters (5/6, Steenhuysen) reports, “The reclassification could change Alzheimer’s research, diagnosis and approaches to treatment, according to the researchers, whose study was published in the journal Nature Medicine.”

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— “The New York Times (requires login and subscription)

Healio (5/6, Young) reports, “A literature review revealed that clinicians more often assigned psychotic and childhood disorder diagnoses to Black vs. white patients, according to a poster presented at the American Psychiatric Association annual meeting.” Investigators “found that clinicians more often assigned psychotic and childhood disorder diagnoses to Black patients vs. white patients, and that white patients were more likely diagnosed with adjustment disorder or ADHD.” The “researchers wrote that ‘unconscious bias and underlying societal structures’ may lead to Black patients receiving more severe diagnoses than their white counterparts.”

Related Links:

— “More research needed on racial bias in diagnosing oppositional defiant disorder,”Kate Young, Healio, May 6, 2024

CNN (5/6, Rogers ) reports, “A daily spoonful of olive oil could lower your risk of dying from dementia, according to a new study by Harvard scientists” published in JAMA Network Open. Among “more than 92,000 adults observed over 28 years, consuming at least 7 grams – a bit over half a tablespoon – of olive oil daily was linked with a 28% lower risk of dementia-related death, compared with those who never or rarely ate olive oil, found the study published Monday.”

MedPage Today (5/6, George ) says, “The relationship remained significant after adjusting for diet quality, including adherence to a Mediterranean diet, and after accounting for APOE4 gene status, the researchers reported.” Additionally, “replacing 5 g (about 1 teaspoon) of margarine and mayonnaise with the equivalent amount of olive oil daily was associated with an 8-14% lower risk of dementia mortality, they noted. Substitutions for other vegetable oils or butter were not significant.”

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— MedPage Today (requires login and subscription)

The New York Times (5/4, Baumgaertner ) reported, “Thanks to advancements in medicine and insurance, mortality rates for children in the United States had been shrinking for decades. But last year, researchers uncovered a worrisome reversal: The child death rate was rising.” Now, “a new study, published Saturday in The Journal of the American Medical Association, revealed growing disparities in child death rates across racial and ethnic groups.” Specifically, “Black and Native American youths ages 1 to 19 died at significantly higher rates than white youths – predominantly from injuries such as car accidents, homicides and suicides.”

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— “The New York Times (requires login and subscription)

CNN (5/4, McPhillips ) reported, “Deaths from drug overdoses and firearm-related injuries have reached record levels in the United States in recent years, and it’s created a ‘double burden’ for children who face an increased risk of losing their parents and of dying themselves, according to the authors of a new study” published in JAMA. Over “1 million children have lost a parent to a fatal drug overdose or gun violence over the past two decades, according to the study, published Saturday…and the burden has increased significantly over time.” Almost “100,000 children lost parents to a drug overdose or gun violence in 2020 alone – almost three times more than in 1999, the study found. These two causes of death accounted for 23% of all parental loss in 2020, nearly double the share from 1999.”

Related Links:

— “Nearly 100,000 children in the US lost a parent to a drug overdose or gun violence in 2020, study finds,”Deidre McPhillips, CNN, May 4, 2024