Pharmacogenomic Testing For Medication-Gene Interactions In MDD May Reduce Prescription Of Medications With Predicted Medication-Gene Interactions But Have Small, Nonpersistent Effects On Symptom Remission, Investigators Conclude

MedPage Today (7/12) reports, “While use of pharmacogenomic testing reduced antidepressant prescriptions with known” medication-gene “interactions in patients with major depressive disorder (MDD), the effects on remission did not persist over time,” researchers concluded. The randomized trial revealed that “among over 1,900 patients, those in the pharmacogenomic-testing group were significantly less likely to be prescribed antidepressants with moderate (30% vs 54.6% in usual care) or substantial (10.7% vs 19.7%)” medication-gene interactions. The findings were published online July 12 in JAMA.

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