Research Finds Individuals With Epilepsy, Depression Have Higher Psychiatric Comorbidity Burden Linked To Shorter Duration Of Initial Therapy, Higher Risk Of Treatment Failure

Healio (12/10, Herpen) reports, “Individuals with epilepsy and depression had a higher psychiatric comorbidity burden linked to shorter duration of initial therapy and a higher risk of treatment failure, data show.” According to the “results, patients with depression remained on [first-line epilepsy therapy] for a shorter time (median 145 days) than those who did not have depression (median 173 days), although durations across subsequent [lines of therapy] were similar between cohorts, featuring modest declines over time.” The findings were presented at the American Epilepsy Society annual meeting.

Related Links:

— “Depression in epilepsy linked to higher comorbidity burden, risk of treatment failure,”Robert Herpen, MA , Healio, December 10, 2025

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