Research by Lauren Osborne, M.D., reproductive psychiatrist at NewYork-Presbyterian and Weill Cornell Medicine, has identified a potential biomarker for postpartum depression (PPD). Examining the metabolic progesterone pathway throughout pregnancy showed that a lower pregnanolone-to-progesterone ratio and elevated isoallopregnanolone in the third trimester were associated with PPD risk. Further investigation may help determine who can benefit from earlier treatment intervention.
Related Links:
— “Dr. Lauren Osborne: Research Uncovers a Potential Biomarker for Postpartum Depression Risk, NYP, February 5, 2026