MedPage Today (2/24, Rudd) reports a study presented at the Conference on Retroviruses and Opportunistic Infections 2026 found that “people with HIV didn’t have a significant rise in depressive symptoms after starting semaglutide (Ozempic, Wegovy, Rybelsus) for diabetes or weight loss.” Researchers observed that “after a median 9.4 months of follow-up, the mean change in depressive symptom scores on the Patient Health Questionnaire-9 (PHQ-9) was -0.1 after participants initiated the drug.” They noted that “scores on the PHQ-9 increased 1.2 for those with no or minimal depression symptoms at baseline and declined by 4.7 points among those with moderately severe to severe symptoms.”
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