Psychiatric News (10/3) reported a study found that “women with pre-menstrual dysphoric disorder (PMDD) who received hormonal suppression with leuprolide experienced an elimination of their mood symptoms, and after the ‘add-back’ of hormones, those symptoms returned.” Researchers observed that “of the 34 PMDD responders, 13 (38%) had symptom recurrence for at least one of the four mood symptoms during both estradiol add-back and progesterone add-back. An additional seven women (21%) had symptom recurrence only during progesterone add-back, and four (12%) had symptom recurrence only during estradiol add-back. In contrast, bloating and food cravings remained elevated regardless of hormone condition, while breast pain was reported as slightly more severe during estradiol add-back.” The study was published in the American Journal of Psychiatry.
Related Links:
— “Response to Hormonal Suppression, Hormonal Add-Back Distinguishes Women With PMDD, Psychiatric News, October 3, 2025