Healio (8/5, Herpen) reports a study presented at the Alzheimer’s Association International Conference links a history of traumatic brain injury to “long-term cognitive decline involving speech functions, specifically where the presence of amyloid-beta was detected as opposed to other biomarkers indicative of preclinical Alzheimer’s.” Researchers observed that “in those positive for amyloid-beta biomarkers, a history of TBI was associated with accelerated longitudinal decline in speech measured by words per minute and letter fluency as well as word finding, while those without TBI had a slight longitudinal increase across all three domains. Further, they reported a decline of broader executive functions such as digital symbol substitution and trails making test were not accelerated by TBI history.” Conversely, they noted “no significant effect of TBI history on similar decline for participants with history of either apolipoprotein or tauopathies.”
Related Links:
— “TBI linked to long-term cognitive decline in preclinical Alzheimer’s disease,”Robert Herpen, MA , Healio, August 5, 2025