According to HCPlive (1/12, Walter), an 85,490-participant study “examined the genetic architecture of treatment resistant schizophrenia (TRS) through the reassessment of genetic data from schizophrenia studies and its validation in ascertained clinical samples.” The study revealed that “treatment resistance is generally a polygenic trait with detectable heritability of 1-4%,” and there also appears to be “a positive association between TRS and a history of taking clozapine.” The findings were published online Jan. 12 in JAMA Psychiatry.
Related Links:
— “Genetic Data Explains Treatment Resistant Schizophrenia “Kenny Walter, HCPlive, January 12, 2022