MedPage Today (9/23, Walsh) reports, “Veterans with rheumatoid arthritis (RA) who had concurrent post-traumatic stress disorder (PTSD) and depression or anxiety were at increased risk for early discontinuation of treatment,” investigators concluded in an analysis that “included 15,081 prescriptions for methotrexate given to 15,081 individuals and 8,412 prescriptions for a TNF inhibitor given to 7,092 patients.” After adjusting for confounding factors, researchers found that “the likelihood for stopping treatment with methotrexate was found to be higher for RA patients with PTSD,” and that “RA patients with PTSD were more likely to discontinue treatment with” a TNF inhibitor. The findings were published online Sept. 13 in ACR Open Rheumatology.
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