The New York Times (2/3, A1, Forsythe, Bogdanich) reports, “McKinsey & Company, the consultant to blue-chip corporations and governments around the world, has agreed to pay $573 million to settle investigations into its role in helping ‘turbocharge’ opioid sales, a rare instance of it being held publicly accountable for its work with clients.” The firm “has reached the agreement with attorneys general in 47 states, the District of Columbia and five territories, according to five people familiar with the negotiations.” The settlement “comes after lawsuits unearthed a trove of documents showing how McKinsey worked to drive sales of Purdue Pharma’s OxyContin” pain medication “amid an opioid epidemic in the United States that has contributed to the deaths of more than 450,000 people over the past two decades.”

Related Links:

— “McKinsey Settles for Nearly $600 Million Over Role in Opioid Crisis ” Michael Forsythe and Walt Bogdanich, The New York Times, February 3, 2021

Healio (2/3, Miller) reports, “The percentage of fatal overdose cases in Philadelphia with detectable levels of xylazine rose from 2% to 31% during a 10-year period, suggesting that the United States’ opioid epidemic ‘continues to evolve,’” investigators concluded after analyzing “data on overdose deaths from heroin, fentanyl or both from the Philadelphia Medical Examiner’s Office.” The findings were published online in the journal Injury Prevention.

Related Links:

— “Xylazine found in one-third of fatal opioid overdoses in Philadelphia “Janel Miller, Healio, February 3, 2021

Reuters (2/3, Terhune, Levine) reports, “Newly unsealed court documents and other records show that Merck & Co and U.S. regulators knew about reports of suicidal behavior in men taking the company’s anti-baldness treatment Propecia [finasteride] when they decided not to warn consumers of those potential risks in a 2011” label update of the medication. In late January, “internal records from Merck were made public…when a federal magistrate in Brooklyn, New York, granted a 2019 Reuters motion to unseal 11 documents filed in years of litigation alleging Propecia caused persistent sexual dysfunction and other harmful side effects.” Following “the 2011 decision on the warning, the FDA has received more than 700 reports of suicide and suicidal thoughts among people taking Propecia or generic versions of the drug.”

Related Links:

— “Exclusive: Merck anti-baldness drug Propecia has long trail of suicide reports, records show ” Dan Levine, Chad Terhune, Reuters, February 3, 2021

CNN (2/2, Marples) reports a study by the Harvard School of Dental Medicine found “34% of adults ages 18 to 25 misused their psychoactive medications,” which include “opioids, stimulants, tranquilizers and sedatives.” The analysis of “surveys of U.S. youth and young adults taken between 2015 and 2018” also found “over 20% of youth ages 12 to 17 who took psychoactive medications were also found to be misusing these drugs.” The findings were published Tuesday in the British Medical Journal.

Related Links:

— “Over one-third of young adults misuse psychoactive medications, study says “Megan Marples, Megan Marples, February 2, 2021

Healio (2/2, Downey) reports, “Cannabis use disorder was associated with self-harm, all-cause mortality, unintentional overdose death and homicide among youth with mood disorders,” investigators concluded after examining data on “204,780 youths aged between 10 and 24 years with a diagnosis of a mood disorder between July 1, 2010, and Dec. 31, 2017.” The findings were published online Jan. 19 in JAMA Pediatrics.

Related Links:

— “Cannabis use disorder a risk marker for self-harm among youths with mood disorders “Ken Downey Jr., Healio, February 2, 2021

NPR (2/2, Chatterjee) reports, “An abrupt spike in suicide deaths among students in the Clark County School District has officials in the Las Vegas district wondering if pressures brought on by the coronavirus pandemic might have been part of what fueled” that rise. NPR talked to medical professionals “at hospitals in seven states across the country, and all of them reported a similar trend: More suicidal children are coming to their hospitals – in worse mental states.” Meanwhile, psychiatrists and other physicians “who work with children say the pandemic has created a perfect storm of stressors for kids,” exacerbating “an ongoing children’s mental health crisis.”

Related Links:

— “Child Psychiatrists Warn That The Pandemic May Be Driving Up Kids’ Suicide Risk “Rhitu Chatterjee, NPR, February 2, 2021

The New York Times (2/1, Blinder) reports, “College football players sustained far more concussions during practices than they did in games,” research indicates.

MedPage Today (2/1, George) reports, “College football players were more likely to have concussions and head hits during practices and preseason training rather than regular season play,” investigators concluded in “an observational study of National Collegiate Athletic Association…Division I players.” The study revealed that “in six NCAA teams across five pre-pandemic seasons, 72% of concussions and 67% of head impacts occurred during practices,” and “roughly half of all concussions occurred during preseason training, even though preseason training represented just 21% of the whole season.” The findings were published online in a brief report in JAMA Neurology.

Related Links:

— “Football Practices Pose More Concussion Risk Than Games, Study Suggests “Alan Blinder, The New York Times, February 1, 2021

NPR (1/29, Mann) reported President Biden is facing criticism for his handling of the ongoing opioid epidemic, which has received less attention during the COVID-19 pandemic. Some critics have pointed to his decision to delay guidelines that would have eased access to buprenorphine as a misstep.

Related Links:

— “With Biden Team Focused On Other Crises, Experts Say Drug Epidemic Is Exploding “Brian Mann , NPR, January 29, 2021

Healio (1/29) reported, “Risk drinking levels increased significantly from 2001 and 2002 to 2012 and 2013,” researchers concluded after using “logistic regression to analyze data of 26,655 current drinkers who were included in the 2001 to 2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) and of 25,659 included in the 2012 to 2013 NESARCIII.” The findings were published online Jan. 21 in the American Journal of Psychiatry, a publication of the American Psychiatric Association.

Related Links:

— “WHO risk drinking levels provide metric for nonabstinent reduction, study finds “Joe Gramigna, Healio, January 29, 2021

Psychiatric News (1/29) reported, “Patients who have depression and frequently experience bouts of anger may have an increased risk of developing bipolar disorder,” investigators concluded in a study that also revealed “a link between aggression reactivity – aggressive behavior in response to feeling threatened, provoked, or frustrated – and conversion to bipolar disorder.” Researchers arrived at these conclusions after analyzing “data from 1,585 people with depression who participated in the Netherlands Study of Depression and Anxiety…a longitudinal study of adults aged 18 to 65 years.” The findings were published online Jan. 27 in the journal Depression & Anxiety.

Related Links:

— “Anger, Aggression Reactivity in Depression May Signal Risk for Converting to Bipolar Disorder, Psychiatric News, January 29, 2021