MedPage Today (5/21, George) reports a study suggests that “greater structural brain integrity appeared to buffer the cognitive consequences of Alzheimer’s disease pathology.” The researchers “evaluated two markers of brain reserve – brain-predicted age difference (brain-PAD) and a volumetric Alzheimer’s disease signature – in cognitively unimpaired older adults. Brain-PAD, a marker of overall structural brain health, uses MRI data to determine how much older or younger a brain appears relative to chronological age.” Overall, researchers observed that “brain-PAD moderated the association between Alzheimer’s pathology and multiple cognitive domains, including episodic memory (β = -0.09), processing speed (β = -0.08), working memory (β = -0.10), and executive function/attentional control (β = -0.08).” The study was published in Neurology.
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