Neurology Advisor (5/15, Saha) reported a study found that “cognitive reserve is associated with delayed symptom onset and slower clinical progression among individuals with dominantly inherited Alzheimer disease (AD).” Researchers observed that among asymptomatic carriers of dominantly inherited AD, “a 1 SD increase in cognitive reserve was associated with higher odds of remaining clinically unimpaired (odds ratio [OR], 3.66). A 1 SD increase in the cognitive biomarker component was also associated with greater odds of remaining unimpaired (OR, 7.77), whereas the demographic component was not significantly associated (OR, 1.24). Among symptomatic carriers, a 1 SD increase in cognitive reserve was associated with a 0.83-fold reduction in baseline CDR-SB score, while a 1 SD increase in the biomarker component was associated with a 0.60-fold reduction.” The study was published in Neurology.
Related Links:
— “Cognitive Reserve Delays Symptom Onset in Dominantly Inherited AD,”Rajan Saha, Neurology Advisor, May 15, 2026